Posts Tagged ‘melatonin’

Insomnia Cure Bred from Mother Nature and Israel

Tuesday, July 20th, 2010

Insomnia

Circadin® “not only improves the onset of sleep, but also improves the quality of sleep” says Nava Zisapel, company founder and Chief Scientific Officer of Neurim Pharmaceuticals. Dr. Zisapel, a Professor of Neurobiology at Tel Aviv University, reports that people who take the drug “have better daytime functioning and an improved quality of life.” The drug stimulates the body’s natural melatonin production. Her prolonged release formula of a mere 2mg dosage mimics the pineal gland’s production of the sleep inducing hormone. Melatonin production normally begins at dark, peaks at around 2am, and then gradually disappears at daylight. Dr. Zisapel began her work in 1992 and she received approval to market it in 2007. The European Medicines Agency (EMEA) at that time approved it for the short term (3 week) treatment of primary insomnia in patients over 55 years of age. The drug, unlike traditional sedatives, does not impair cognitive functions the following day, nor does it impair psychomotor skills. There are no abuse or dependency risks. Insomniacs, numbering nearly a third of the world’s population, will be cheered by the European Commission’s July, 2010 approval to expand the treatment duration from 3 weeks to 13 weeks. Circadin® is the first insomnia treatment approved for the extended length of time. It is currently marketed in Australia, Thailand, and Israel. US, Asian, and Latin American markets are in the registration process.

Insomnia, defined as the “difficulty to initiate or to maintain sleep,” affects almost all adults at one time or another. Transient (symptoms less than a week) insomnia and short term insomnia (one to three weeks) can occur as a result of jet lag, indigestion, shift work schedule changes, noisy sleep environments, stress, and recent medical situations. Long term (more than 3 weeks) or chronic insomnia is usually caused by psychological or medical conditions such as depression, pain, heart disease, acid reflux, asthma, sleep apnea, Parkinson’s disease, Alzheimer’s, brain tumors and strokes. Delayed or untreated insomnia costs America $42 billion dollars a year in healthcare costs. The seriously sleep deprived insomniacs have been limited to prescription sleep aids with their risks of dependency and abuse, or to over the counter antihistamines with their residual drowsiness hazards. The FDA has consistently discouraged natural supplements since they have no jurisdiction over them. They have issued warnings against the use of the natural alternatives of valerian, melatonin, and kava.

Circadin® is now in use in over 33 countries. It is naturally preferable to prescription sleep aids and their over the counter competitors.  It’s time for the FDA to approve it for the sleepless and tired insomniacs of the USA. Everyone deserves a good night’s rest!

Copyright 2010. All rights reserved to Ronald Czarnecki.

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Blue Light and Yellow Goggles: Essential Equipment for Sleep and Mood?

Tuesday, May 18th, 2010

Blue Light Box

 

Yellow Goggles

Blue light therapy and yellow goggles are becoming essential equipment for sleep disorders, for depression, and for seasonal affective disorder. Advanced sleep phase syndrome, delayed sleep phase syndrome, periodic insomnia, shift work sleep disorders, and jet lag are all related to circadian rhythm interruptions. Photoreceptor cells in the retina have been discovered that are directly linked to the “circadian pacemaker” of our brain: the pineal gland. The pineal gland produces melatonin which is the hormone responsible for our sleep-wake cycle. Daylight suppresses melatonin production and darkness stimulates its production, increasing sleepiness. Kate Le Page, in a recent article, traced the birth of light box therapy to the sanatoria of Europe in the 1870s. Sunlight was found beneficial to the treatment of bacterial diseases common at the time. Scandinavian countries, where the sun is in short supply for much of the year, have taken light therapy more seriously than the rest of the world. A light “shot” can be found on the menu in Finland cafes where you can drink your coffee while receiving your light therapy at the table. Sweden has equipped many cold war bomb shelters with full spectrum lights for therapy purposes. Russia is using light therapy to reduce worker sick days and to increase productivity. Their research has found a link between light therapy and an increase in the body’s ability to cope with pollutants and to boost immunization effectiveness.

Steven Lockley, Charles Czeisler, and George Brainard have done extensive studies on the utilization of blue light to combat sleep issues. They have found that blue light contains more energy than white light and it can be more efficient utilizing less time and energy to alter the sleep-wake cycles. Lockley, in the Harvard University Gazette, suggests that blue light “may be a powerful countermeasure for the negative effects of fatigue for people who work or study at night.” Blue light proved more beneficial than green light in reducing sleepiness, speeding reaction times, and focusing attention.

Dr. Joshua Gooley, in Annals Academy of Medicine, details more specific prescriptions:

  • For later sleep-wake times and phase delay shift:
    • Evening bright light therapy before bed, dim light after wake time.
  • For earlier sleep-wake times and phase advance shift:
    • Morning bright light therapy after wake time, dim light prior to bedtime.
  • For entrainment of sleep-wake cycle and phase advance shift:
    • Morning bright light therapy after wake time, when sleep episode occurs during night.
  • For adaptation to shift work and large phase delay shift:
    • Bright light therapy in evening/night, dim light after work, strict adherence to regular sleep-wake times.
  • For jet lag, eastward travel, and phase advance shift:
    • Morning bright light therapy after wake time (home time), dim light prior to bedtime.
  • For jet lag, westward travel, and phase delay shift:
    • Evening bright light therapy before bedtime (home time), dim light after wake time.

Blue light boxes are available from many sources. The time required to affect a shift should be 15 to 30 minutes over a period of a couple of days. The light source should be placed 1 to 2 feet above the subject and not directly in line with the eye. The photoreceptors linked to your circadian pacemaker detect the light from the bottom of the retina. During dim light periods yellow goggles should be worn for 1 to 2 hours in order to filter out the blue light spectrum.

The best information I found on light therapy for treating depression and seasonal affective disorder (SAD) comes from psycheducation.org. Light therapy was proven to be as effective as antidepressant medication therapy with far fewer side effects. Its use, however, for depression and SAD should take place under a doctor’s supervision. Treatments were initiated at 30 minutes a day and decreased to 15 minutes for maintenance through the winter months. If you are a night owl, your treatment should occur as late as 8 or 9 am. If you are a lark, your treatment should occur as early as 5 am. The therapy works best when applied 8 to 9 hours after the onset of melatonin secretion. The time will be relative to your particular circadian rhythm. An excellent quiz to help determine your rhythm and optimum treatment times and durations can be found at cet-surveys.org.

Get ready for the blue lights and the yellow goggles. Before too long they will be mandatory equipment for our sleep deprived and depression plagued world. Until then, enjoy the sun and the natural cheer it brings!

Copyright 2010. All rights reserved to Ronald Czarnecki.

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Deadly Sleep Habits

Saturday, January 30th, 2010

This post is reprinted with permission from the author, Beth Terry, who has a great website called the “Cactus Wrangler.” She has many excellent articles. This one, well written and well researched suits our topic. I have added her site to the links. You might also check out the video link I added from Steve Savage at Vimeo. It follows Beth’s article.

Here’s the deal: If you want to be Resilient, you’ve GOT to get enough sleep!

~ Sleep deprivation can kill you.

~ Waking you up in the middle of REM (Rapid Eye Movement or deep sleep) will make you tired all day, even if you went back to sleep and got a total of 8 hours. If you are awakened when you are not in REM sleep, you are not as affected by the interruption.

~ Light stops the production of melatonin, which helps you sleep. Even if you keep your head covered, and any part of your body is exposed to light, you lose the benefits that melatonin affords your body in helping you regenerate.

~ Your brain and body are very busy while you sleep. Cells are repaired, ‘tanks’ are refilled (endorphin, adrenal, thyroid, etc.) Your brain takes the millions of bytes and bits of information you collected during the day and puts them in order. It busily arranges data, dumps data you don’t need, and helps strengthen your memory. Get fewer than 6 hours of sleep and these processes don’t function properly.

~ Reuters reported on a “study by German researchers at the University of Luebeck”. The study showed your sleeping brain undergoes specific changes that lead to creativity and problem-solving insights the next day. This typically happens during “slow wave” deep sleep that occurs in the first four hours of the sleep cycle–but you need a full 8 hours to gain the benefits. Waking up too soon, or being startled awake can stop or reverse the processes.

Think of your computer. What happens if you give it a complex task, say, backing up, and you turn the computer off midway through the task? Kablooey! (That’s a technical term.)

One scientist claims that our kids would learn better if we started school at 9AM instead of 7:30, and kept them until 3 or 4 in the afternoon.

~ Teenagers need to sleep more than adults. They are getting mugged by their hormones, and their brains and bodies are assimilating huge masses of data. One scientist claims that our kids would learn better if we started school at 9AM instead of 7:30, and kept them until 3 or 4 in the afternoon. And parents might see a calmer kid if they let’em sleep when they need to.

~ And yes, you can get too much sleep. Two recent studies reported by Scientific American claim that adults who sleep more than 8 hours have a shorter life span, too. So you do need to have some balance.

~ Dr. Rafael Pelayo of Stanford University’s Sleep Disorder Clinic says unequivocally that sleep deprivation is dangerous. And sleep deprivation is cumulative. So you need to give yourself a chance to catch up! Your life depends upon it.

According to Dr. Pelayo this is what happens:

* You will have problems with memory and concentration.
* You will have problems finding the right word.
* You will become irritable.
* Neurotransmitters in your brain are altered.
* You become more susceptible to infection.
* At its extreme, sleep deprivation leads to death

So, kids, when you feel like taking a nap, maybe you should. If you are driving, pull off to a safe place and catch 20 minutes of sleep. If you are tired at work, take a power nap at lunch. If you’re a night owl, plan it so your meetings don’t start till later in the day.

And knock off the 24/7 work schedule. Don’t give yourself too much credit! The world goes on within you and without you. If you don’t make it in to work tomorrow, we’ll figure it out. We might miss you, but we’ll get along OK.

Give your body and your brain a fighting chance, and they’ll serve you (and your community) well for many years to come!

I think I’ll go take a nap….

Beth

~~~
Beth Terry, CSP
Professional Speaker and Author
Website

© 2010 Beth Terry Seminars, Inc. All Rights Reserved

from ? Real Life, Resilience, Sleep Studies, Values to Live By, Work Ethic

This post has been reprinted with full permission of Beth Terry.

Take a look now at this video from Steve Savage: You can watch it here:
http://vimeo.com/groups/hv30/videos/8914…

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