Posts Tagged ‘sleep apnea’

Insomnia Cure Bred from Mother Nature and Israel

Tuesday, July 20th, 2010

Insomnia

Circadin® “not only improves the onset of sleep, but also improves the quality of sleep” says Nava Zisapel, company founder and Chief Scientific Officer of Neurim Pharmaceuticals. Dr. Zisapel, a Professor of Neurobiology at Tel Aviv University, reports that people who take the drug “have better daytime functioning and an improved quality of life.” The drug stimulates the body’s natural melatonin production. Her prolonged release formula of a mere 2mg dosage mimics the pineal gland’s production of the sleep inducing hormone. Melatonin production normally begins at dark, peaks at around 2am, and then gradually disappears at daylight. Dr. Zisapel began her work in 1992 and she received approval to market it in 2007. The European Medicines Agency (EMEA) at that time approved it for the short term (3 week) treatment of primary insomnia in patients over 55 years of age. The drug, unlike traditional sedatives, does not impair cognitive functions the following day, nor does it impair psychomotor skills. There are no abuse or dependency risks. Insomniacs, numbering nearly a third of the world’s population, will be cheered by the European Commission’s July, 2010 approval to expand the treatment duration from 3 weeks to 13 weeks. Circadin® is the first insomnia treatment approved for the extended length of time. It is currently marketed in Australia, Thailand, and Israel. US, Asian, and Latin American markets are in the registration process.

Insomnia, defined as the “difficulty to initiate or to maintain sleep,” affects almost all adults at one time or another. Transient (symptoms less than a week) insomnia and short term insomnia (one to three weeks) can occur as a result of jet lag, indigestion, shift work schedule changes, noisy sleep environments, stress, and recent medical situations. Long term (more than 3 weeks) or chronic insomnia is usually caused by psychological or medical conditions such as depression, pain, heart disease, acid reflux, asthma, sleep apnea, Parkinson’s disease, Alzheimer’s, brain tumors and strokes. Delayed or untreated insomnia costs America $42 billion dollars a year in healthcare costs. The seriously sleep deprived insomniacs have been limited to prescription sleep aids with their risks of dependency and abuse, or to over the counter antihistamines with their residual drowsiness hazards. The FDA has consistently discouraged natural supplements since they have no jurisdiction over them. They have issued warnings against the use of the natural alternatives of valerian, melatonin, and kava.

Circadin® is now in use in over 33 countries. It is naturally preferable to prescription sleep aids and their over the counter competitors.  It’s time for the FDA to approve it for the sleepless and tired insomniacs of the USA. Everyone deserves a good night’s rest!

Copyright 2010. All rights reserved to Ronald Czarnecki.

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Sleep and the Cell Phone: Insomnia Stimulant or Gateway to a Cure?

Tuesday, June 29th, 2010

The bedtime cell phone calls

A recent survey found that 82% of Americans don’t leave home without their cell phones and 50% of Americans sleep with their phones nearby. 56% of Americans regularly use the alarm clock feature. Globally 67% use the alarm clock feature requiring them to have their cell phones in close proximity to their beds. Texting has become the focus of communication for teens today. 87% of the texting teens admitted to sleeping with, or next to, their phones. With a third of US teen cell phone owners texting more than a 100 texts a day, many of these are occurring at night while in bed. Cell phone use has been found to reduce sleep. Its use at bedtime, according to research detailed by Geoffrey Lean in The Independent, increases the time it takes to reach the deeper stages of sleep and decreases the time spent in those valuable stages of sleep. Deep sleep deprivation “can lead to mood and personality changes, ADHD-like symptoms, depression, lack of concentration and poor academic performance.”

The study, funded by the Mobile Manufacturer’s Forum, embarrassed themselves with the scientists’ findings that “components of sleep believed to be important for recovery from daily wear and tear are adversely affected by exposure to 884 MHz wireless signals.”  The researchers believed that the radiation was activating the brain’s stress system making the subjects “more alert and more focused, and decreasing their ability to wind down and fall asleep.” Almost half of the people in the study also reported to be “electrosensitive” experiencing headaches and impaired cognitive functions.

A much larger study followed 1656 Belgian teenagers for a year. The research found that most of them used their phones after going to bed. Those that did so once a week were three times more likely to report feeling “very tired” than those who did not use them in bed. Those who used them in bed more than once were five times more likely to report feeling “very tired.” Dr. William Kohler of the Florida Sleep Institute said “Anything that disrupts the integrity of your sleep will potentially have adverse consequences in functioning during the day, such as grouchiness, difficulty concentrating, and in children hyperactivity and behavior problems.”

James Horne and his colleagues at the Loughborough University Sleep Research Center in England found that cell phone signals disrupted brain wave patterns “long after” the cell phones were turned off. The subjects in his study, as described by Douglas Field in Scientific American, also had difficulties falling asleep. They found that delta wave patterns characteristic of stage two sleep (50% of total sleep) were negatively affected for nearly an hour after the phone was shut off. His findings and those of others are stimulating additional research into electromagnetic radiation and its affect on mental behaviors. Sensitivity to such low level radiation raises concerns of mind control.

The cell phone, while exhibiting negative influences on deep sleep, is soon to become a critical tool to the sleep deprived. Dr. Phillip Low has found the way to link a single channel EEG to a SPEARS algorithm which is capable of mapping an entire night’s worth of brain activity. His company, NeuroVigil, uses an adhesive, wireless sensor or a head strap to monitor the brainwave activity. “NeuroVigil’s sleep monitoring solution streams and records the patient’s EEG data through their cell phone or smartphone.” Dr. Low, a 30-year-old neuroscientist is about to market his iBrain device (the size of two pennies) which, according to Daniel Heimpel of the Huffington Post, will “revolutionize the study of sleep, speed the diagnosis of disease, and tap into the multibillion dollar sleep and neurodiagnostics markets.” Until now, sleep tests have averaged more than $3,000. The cost has been prohibitive for the more than seventy million Americans suffering from sleep disorders. The sleep tests have previously required hook-ups to multiple electrode systems and overnight stays in uncomfortable strange laboratory environments not at all conducive to regular sleep patterns.

The data from the iBrain may unlock keys to cures and/or medications for sleep apnea, insomnia, and other sleep disorders. It will assist in the pre-market testing of pharmaceuticals of the future. The pharmaceutical companies, the Defense Departments, and the transportation industries are all knocking on Dr. Low’s door. They would all like a piece of Dr. Low’s brain as well as his company but he has decided to run his company on his own terms.

Dr. Low’s brain, the iBrain, and your cell phone may provide the keys to the gateway of your brain…and the solution to your sleep problems. A dream comes true?  

Copyright 2010. All rights reserved to Ronald Czarnecki.

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Miracle Anti-Snore Pill to Remedy Sleep Apnea and Sleep Deprived Victims?

Monday, February 8th, 2010

A miracle pill may be on the horizon to help sleep apnea victims. The pill could offer the solution to a good night’s rest for both the sleep apnea patient and their sleep deprived partners. If this pill proves to be as successful in future studies as it has been in a recent six-month study it will become the “holy grail of snoring therapy.”

According to Pat Hagan, writing in MailOnline, “the once-a-day pill slashed snoring rates by almost 70 per cent in a small U.S. trial.” Approximately  three million people are affected by sleep apnea in Britain. The U.S. has approximately thirty million victims. During an Obstructive Sleep Apnea (OSA) episode the throat actually closes and air passage to the lungs is blocked. These episodes can last anywhere from ten seconds to two minutes. The victim’s life is saved by waking up. The brain, realizing that breathing has stopped, sends a signal for airway muscles to contract again, opening the airway and waking the victim “with a jolt and a snore.” This death defying cycle can occur hundreds of times a night.

The result of these frequent interruptions of sleep for both the victim and his partner is severe sleep deprivation. The usual symptoms then appear during the day: tired and exhausted feelings, confusion, depression and irritability, reduced sex drive, heartburn, headaches, high blood pressure, and possibly heart problems. The consequences of these symptoms can result in heart attack, stroke, or fatal accidents. 

“The new drug, called Qnexa, was developed as a weightloss medicine. It contains a mixture of a stimulant drug called phentermine and an anti-epilepsy drug called topiramate.

Researchers noticed an added benefit when they tested volunteers to measure the effects on sleep apnea.

Over the course of the trial, which involved men and women aged 30 to 65, the number of times their sleep was disrupted by snoring-related problems dropped from an average of 46 times an hour to just 14.

At the same time, they lost an average of 10 per cent of their body weight and saw a significant drop in blood pressure. Vivus Inc, the California drug firm that developed Qnexa, says it hopes to get it licensed to treat sleep apnea.”

The 70% cut in snoring rates looks very promising. More extensive testing is being done as we speak. Qnexa may be the next miracle drug to help millions of people get the “good night’s rest” we all deserve.

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A Stress Reliever Remedy from the Good Old Days?

Friday, December 25th, 2009

A couple of days ago, I was sitting in the barber’s chair “getting my ears lowered.” My grandfather always referred to a haircut that way, but you hardly hear that expression anymore. I actually like it, because you can’t accurately call one of my visits a haircut. My instructions are usually just “trim around the back and sides, but leave the top.” Not much hair to cut anymore! “Lowering the ears” is a much  more accurate  description. My grandfather had the same problem I have with hair: very little there.

My barber, who I’ll call Dan, for the sake of his anonymity, was telling me about his problem with sleep apnea. Dan said that he usually only slept three to four hours a night. How anyone can get by with only three to four is beyond my comprehension. Dan told me that quite some time ago he had been diagnosed with sleep apnea and he had been given all the CPAP paraphernalia. Unfortunately, he was only able to use it a very short time because he discovered that he was allergic to the material used in the mask. His face broke out with a serious rash everytime he used the CPAP machine. He was embarrassed to go out in public. Dan suffered with his sleep problem for some years after.

Dan found himself sleeping less and less each night.  He was constantly tired, had no energy, and felt too depressed to play golf, his favorite stress reliever. He had to see his doctor again. The doctor visit disclosed that Dan had recently had a minor heart attack. His doctor suggested that his minor heart attack may have been caused by Dan’s sleep apnea, and Dan’s refusal to wear his previously prescribed CPAP gear. Dan’s doctor told him that the gear available now is much improved. Dan would no longer have to wear a mask. The gear today uses a tube inserted into the nostril. The solution has been less successful than Dan had wished. The tube is easily dislodged from the nostril and it often causes nose bleeds.

Dan still tries to use it whenever he can push himself to do so. It does help him sleep a little better now, but the frequent nose bleeds have become a problem. The nose bleed thing is a problem I’ve been dealing with every winter. The dry heat of the furnace in the winter had been affecting me with the same problem. I have had a deviated septum since childhood. I keep telling myself that I’m too old to have that corrected now. Actually, my fear of the surgical procedure has held me back. I am a real coward when it comes to surgery!

Not less than a month ago one of my sons suggested a humidifier for our bedroom. He raved about how well it worked for him and his family. He suggested I get one for the bedroom and one for the family room. I followed his instructions. I bought two Honeywell ”warm mist” humidifiers. The container can easily be put under a bathroom sink faucet. I fill it twice a day; there are no filters to clean; and the cost is only $39.95 per unit. I am absolutely amazed at the difference. I sleep better. I breathe better. My skin is not dried out like it used to be. The nose bleeds are very rare now. I gave this prescription to Dan while he was lowering my ears.

Dan and I continued to discuss the sleep deprivation problem faced by all of us today. I told him about my recent article: “The Real Pandemic of the 21st Century.” We discussed the worries and the stresses plaguing society today: the bad economy, the jobless rate, the home mortgage crisis, the national debt, the declining educational system, the “New World Order,” and the fact that both parents have to work in order to survive today. The causes of sleep deprivation are too numerous and too complicated to remedy.

Dan then described how his family dealt with the stresses and pressures of the day when he was a child. Every night after dinner the entire family would move to the front porch. Everyone had his own chair since the porches then were much larger than they are today. Everyone had his turn to talk about “what went on” in his day. Each followed to offer assistance and possible solutions; or compliments and encouragement. The worries and stresses were “talked out.” The family bond was strengthened through the sharing of each others experiences. They built a missile defense system in each of their brains that could defeat any and all future attacks. Sleep was an easy follow-up to the healthy and prescriptive conversations.

What a great remedy! It’s time for the New Year’s Resolutions everyone! Dedicate  the time to do this every night. After a short time, you won’t have to be the volunteer to go first. The whole family will benefit from this simple, inexpensive prescription!

Thanks, Dan, for your contribution to our blog. The “ears are lowered” and I’m ready for the holiday get-togethers. I hope the humidifier helps you sleep better. Your remedy, however, was far more valuable than mine; and it didn’t cost a penny!

Happy New Year, and Sleep Better!

Copyright 2010. All rights reserved to Ronald Czarnecki.

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